Key benefits of the CNAP^® technology: 
• CNAP^® enables a rapid response to changes in blood pressure to better manage patients 
• Comfort for patients: noninvasive, thus safe monitoring, whilst avoiding the risks of infection of invasive arterial lines
• Easy to use: quick and error-free application for every day use with minimal training required
• Time and cost saving: fixed start-up-time of 90 seconds combined with reusable sensors
• Noninvasive, reliable measurement where invasive arterial lines are not indicated, but continuous measurement is appreciated.

Hemodynamic optimization

• Unique combination of non-invasive blood pressure and PPV

• Volume responsiveness through pulse pressure variation (PPV)

• Cost-effective and easy therapy control

Non-invasive

• Continuous: systolic, diastolic and mean blood pressure and pulse rate

•  Automatic calibration to upper arm blood pressure (NBP)

Accurate

• Accuracy and waveform dynamics are comparable to intra-arterial measurement

Quick and cost-effective

• Easy setup

• Reusable finger sensors

• Connectivity to every standard patient monitor 

The CNAP Monitor 500 HD is the stand alone monitoring device designed for anesthesiologists, cardiologists and researchers:

> Improving patient safety

> Supporting diagnostic excellence

> Enhancing your research work

> Revolutionizing early detection & prevention

COVID-19

A rapid change of hemodynamic status requires daily examination for individualized treatment, using functional hemodynamic tests such as Passive Leg Raising (PLR), End Expiratory Occlusion Test (EEOT) and Mini Fluid Challenge (MFC) at the bedside.

Furthermore, the complex interaction of respiration, right ventricular (RV) function and other cardiovascular factors creates a therapeutic conflict between conservative fluid management vs. hypovolemia from an early stage of COVID-19 (too wet vs. too dry).

CNAP^® Monitor 500 HD provides essential feedback for functional hemodynamic tests to direct volume expansion in patients without invasive line indication:

> Supports healthcare professionals in educated hemodynamic management decisions

> Helps to guide conservative fluid management while preventing hypovolemia

> Simplifies daily examination and individualized treatment

> Quick and easy application with minimal training required

> No burden to patients

> Supports healthcare professionals in daily clinical routine

> Early recognition to prevent deterioration

Goal directed therapy

The CNAP^® finger sensor offers a unique combination of non-inasive and continuous blood pressure, cardiac output and dynamic fluid response parameters.

Therefore the CNAP^® Monitor is the ideal tool for personalized fluid management in low and moderate risk cases.

“Full characterization of fluid responsiveness requires consideration of the type, amount and timing of fluid as well as the expected change in stroke volume. The best method of measuring fluid responsiveness is a continuous or rapidly repeatable measure of stroke volume.[…] Alternative methods for predicting fluid responsiveness include stroke volume variation (SVV), pulse pressure variation (PPV), systolic pressure variation (SPV), and (in certain mechanically ventilated patients) end-expiratory occlusion test and respiratory systolic variation test.” ^[4]

Hypotension

Intraoperative hypotension may cause serious complications such as myocardial injury, acute kidney injury, and death. In the postoperative period, hypotension is common, but remains widely undetected in general care floor settings, and is independently associated with myocardial injury and mortality . “Critical care patients are especially sensitive to hypotension, and the risk appears to be present at blood pressures previously regarded as normal.” ^[5]

Thus, if detected early enough, complications due to hypotensive episodes could be reduced or even avoided.

“Understanding intraoperative events that predict morbidity and mortality could improve perioperative care in surgical patients by preventing events or initiating treatments after adverse events.”^[1]

Non-invasive CNAP^® Monitor enhances perioperative monitoring by providing continuous blood pressure and advanced hemodynamic information even in low and moderate-risk surgeries. Continuous blood pressure monitoring enables hypotensive phases to be detected earlier compared with intermittent NBP monitoring, which helps to improve patient safety.^[6]

ANESTHESIA | CRITICAL CARE 

Obtain a full hemodynamic status including blood pressure, cardiac output and vascular resistance from the unique CNAP^® finger sensor to enhance your diagnosis.

> Real time hemodynamic monitoring of blood pressure, cardiac output and pulse pressure variation

> Accurate feedback on all functional hemodynamic tests

> Supporting healthcare professionals in educated decision making

> Enabling individualized treatment

> Reducing postsurgical complications up to 34% by implementing Goal Directed Therapy

ENHANCED DIAGNOSIS

Obtain a full hemodynamic status including blood pressure, cardiac output and vascular resistance from the unique CNAP^® finger sensor to enhance your diagnosis.

> Improving diagnostic quality by detecting unexpected blood pressure drops often unidentified by standard NBP

> Early detection of rapid and short term hemodynamic changes due to orthostatic challenges and autonomic function tests

> Tracking cardiovascular response to stimuli

> Truly continuous and fully synchronized

> Helps identifying cardiovascular & autonomic diseases

HIGH-LEVEL RESEARCH

Enhance your research work with a full set of truly continuous cardiovascular parameters right from your fingers.

> Collection of continuous non-invasive recordings of arterial pressure and advanced hemodynamics

> Fully synchronized data from one sensor

> Calibrated signals for high accuracy

> Reliable long and short-term measurements

> Clinically proven and validated technology

> Reproducible results

> Easy data storage, export and analysis

> Quick and easy set-up

REVOLUTIONIZING PREVENTION

Benefit from our noninvasive technology in the early detection of cardiovascular diseases.

> Supporting preventative healthcare

> Early detection of cardiovascular diseases

> Help identifying hypertension, stress and sudden cardiac arrest

> Allowing for quick and easy triage in overloaded healthcare systems

> Evaluating cardiovascular status to determine diagnostic pathway

> Assessing efficacy of medication

> Non-invasive, easy to use and without any burden for the patient

References:

[1] Kurz, A., Turan, A., Rodseth, R. N., Cywinski, J., Thabane, L., Ph, D., & Sessler, D. I. (2013). Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery. Anesthesiology, (3), 507–515.

[4] Martin GS, Kaufman DA, Marik PE, Shapiro NI, Levett DZH, Whittle J, MacLeod DB, Chappell D, Lacey J, Woodcock T, Mitchell K, Malbrain MLNG, Woodcock TM, Martin D, Imray CHE, Manning MW, Howe H, Grocott MPW, Mythen MG, Gan TJ, Miller TE. Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance. Perioper Med (Lond). 2020 Apr 21;9:12. doi: 10.1186/s13741-020-00142-8. PMID: 32337020; PMCID: PMC7171743.

[5] Ruetzler K, Khanna AK, Sessler DI. Myocardial Injury After Noncardiac Surgery: Preoperative, Intraoperative, and Postoperative Aspects, Implications, and Directions. Anesth Analg. 2020 Jul;131(1):173-186. doi: 10.1213/ANE.0000000000004567. PMID: 31880630.

[6] Nicklas JY, Beckmann D, Killat J, Petzoldt M, Reuter DA, Rösch T, Saugel B. Continuous noninvasive arterial blood pressure monitoring using the vascular unloading technology during complex gastrointestinal endoscopy: a prospective observational study. J Clin Monit Comput. 2019 Feb;33(1):25-30. doi: 10.1007/s10877-018-0131-6. Epub 2018 Mar 20. PMID: 29556885.

BRIDGING THE GAP WITH NON-INVASIVE AND CONTINUOUS PARAMETERS

Based on an easy-to-use dual finger sensor, the CNAP^® technology provides a full set of non-invasively measuered, continuous patient signals and hemodynamic parameters:

> CNAP^® blood pressure (waveform, Sys, Dia MAP, PR)

> Advanced hemodynamics: Cardiac Output (CO/CI), Stroke Volume (SV/SI), Systemic Vascular Resistance (SVR/SVRI)

> Dynamic fluid management parameters: Pulse Pressure Variation (PPV), Stroke Volume Variation (SVV)

FULL HEMODYNAMIC PICTURE

Get the full hemodynamic parameter-set on our CNAP^® technology: non-invasive, continuous blood pressure, advanced hemodynamics and dynamic fluid parameters.

Continuous Blood Pressure

CNAP^® blood pressure is measured non-invasively on the patient’s fingers by using the unique CNAP^® finger sensor.

Continuous blood pressure measurement allows for the detection of rapid blood pressure changes often unidentified, missed or only belatedly recognized with intermittent NBP upper arm measurement.

One or more hypotensive episodes were detected during complex gastrointestinal endoscopy in 29% of the patients by using CNAP^® technology.^[1]

“Continuous non-invasive arterial pressure measurement facilitates detecting hemodynamic instability more rapidly and therefore may improve patient safety”^[1]

> Preventing perioperative hypotension^[1]

> Identifying unexpected and transient blood pressure drops in syncopal patients^[2]

> Tracking of cardiovascular response to autonomic function tests and stimuli^[3]

Non-invasive Cardiac Output & advanced hemodynamics

The non-invasive CNAP^® finger sensor allows for accurate^[1] and immediate feedback on hemodynamic and cardiovascular status in perioperative settings to support therapeutic decision making, and also to quantify hemodynamic response during orthostatic and autonomic function tests (tilt table, active standing, Valsalva, etc.)^[2] or to track cardiovascular response to autonomic function test and stimuli^[3].

Non-invasive Pulse Pressure Variation and Stroke Volume Variation parameters

PPV and SVV are dynamic fluid parameters enabling individualized intra-operative fluid management, supporting healthcare professionals in educated therapy decisions^[1,2] over the course of Enhanced Surgical Recovery (ESR) and Goal Directed Therapy (GDT) guidelines to minimize postoperative complications^[3,4].

References: 

[1] Benes, J et al. Fluid management guided by a CNAP device is associated with decreased postoperative morbidity after total knee and hip replacement.BMC Anesthesiology, 15(1), 148.(2015)

[2] Renner J et al. Non-invasive assessment of fluid responsiveness using CNAP™ technology is interchangeable with invasive arterial measurements during major open abdominal surgery. Br J Anaesth. 2017 Jan;118(1):58-67. doi: 10.1093/bja/aew399. PMID: 28039242.

[3] Michard, F., Biais, M., Lobo, S. M., & Futier, E. (2019). Perioperative Hemodynamic Management 4.0. Best Practice & Research Clinical Anaesthesiology

[4] Nicklas JY, et al. Personalised haemodynamic management targeting baseline cardiac index in high-risk patients undergoing major abdominal surgery: a randomised single-centre clinical trial. Br J Anaesth. 2020 Aug;125(2):122-132. doi: 10.1016/j.bja.2020.04.094. PMID: 32711724.

UNIQUE CUSTOMERS

--Trust in our CNAP^® technology for more than 20 years

SYNCOPE MANAGEMENT

“We have used the Task Force^® Monitor in our Falls and Syncope Service for 8 years and have 7 machines operational in our unit. We use the TFM for the investigation of syncope, orthostatic hypotension and autonomic function tests and find the monitors very user friendly. We have found both the service and support exceptional. Both the distributors and the manufacturers have always been easy to contact, and have also provided a personal touch to their service. We use the equipment for clinical and research purposes, and are highly satisfied with the data obtainable from the Task Force^® Monitor, as much of the analysis is automated and the information can be transported to a wide range of software applications. We as a department are very happy with the Task Force Monitors.”

-- Pam Reeve, Syncope Unit, Royal Victoria Infirmary Newscastle, UK

AUTONOMIC FUNCTION

“The Task Force^® Monitor has revolutionized ease-of-use in performing and generating data both for research and clinical purposes. I am especially impressed with the amount of information gathered. As a clinical fellow at the NYU Dysautonomia Center I did comparative analysis using this equipment to look at cardiac output and stroke volume and found it to be quite accurate. And the report generated is very informative.”

-- Ishan Adhikari, MD., University of Texas Health Science Center, San Antonio, Texas, USA

CARDIOLOGY

“We chose the Task Force^® Monitor for a large, multi-center NIH study due to its ability to collect beat-to-beat data for heart rate, blood pressure, and baroreceptor sensitivity using novel, non-invasive technology. In addition to it’s ease of use, we have been pleased with both the data quality and the ability to easily export data.”

-- Jeffrey Olgin, M.D., Chief of Cardiology, University of California, San Francisco, USA

RESEARCH

“I think the CNAP^® is great device. I have had extensive experience using the Ohmeda 2300 and the Finometer. I will continue to use our CNAP^® devices in more controlled acute studies because of its ease of use and accuracy. We are also very appreciative of the support from CNSystems and Partners in Medicine.”

-- Jan Berkow, Chief Technology Officer, Intelomed Inc., USA

“Last year we replaced our Colin Pilot units with CNAP^® Monitors. They are being used as part of a longitudinal study that includes measurement of changes in blood pressure over time in young, middle-aged, and older adults. The CNAP^® Monitors have performed reliably and are well tolerated by our subjects.”

-- Louise Hawkley, PhD, Associate Director, The Social Neuroscience Laboratory, University of Chicago, USA

FLUID MANAGEMENT

“Hemodynamic Monitoring with CNAP^® and PPV should extend the positive outcome of goal-directed fluid management beyond high-risk, arterial-line managementor Doppler-monitored surgeries. This would allow fluid management to become an actual clinical standard for the benefit of patients.”

-- Prof. Bennoit Vallet, MD, PhD, University Hospital Lille, France

ANESTHESIA

“The CNAP^® technology enables advanced hemodynamic monitoring even in medium-risk patients and procedures in a fast, easy and noninvasive way.”

-- Prof. Dr. med. Berthold Bein, Anesthesiology and Intensive Care, Asklepios Clinic St. Georg, Hamburg, Germany

“This device, the CNAP^®, has all the features of a disruptive technology.[…] It is only a matter of time until volume clamp devices replace many if not the majority of arterial catheters for the continuous measurement of blood pressure, arterial respiratory variation, and even noninvasive cardiac output monitoring.”

-- Robert H. Thiele, MD, Dpt. of Anesthesia, University of Virginia, USA.

“We just started to use your monitor on high risk orthopedic and bariatric patients at our hospital in Geneva. It is marvellous and a great tool for anesthesia!!”

-- John Diaper, PhD, Dpt. of Anesthesiology, Pharmacology and Intensive Care, University Hospital Geneva, Switzerland

“CNAP^® enables easy-to-apply noninvasive continuous blood pressure measurement allowing for closer blood pressure management during anesthesia and avoids the general risks of an arterial measurement. This provides advantages for patients with difficult vascular status and puncture, short interventions in patients with cardiovascular comorbidity or restrictive indication for invasive measurement […].”

-- Prof. Peter Lauven, Anesthesiology & Operative ICU, Bielefeld, Germany

“The CNAP^® device detected more hypotensive episodes after spinal anesthesia and significantly lower arterial pressure (AP) compared with NIAP. AP monitoring based on CNAP^® may improve haemodynamic management in this patient population with potential benefit for the fetus.” ^[1]

-- Dr. Christoph Ilies, Marienhospital, Stuttgart, Germany

“We have been impressed with the CNAP^® Monitor and would suggest that it can certainly be used instead of an arterial line in some cases. It would make a great adjunct in any OR case when hemodynamic instability develops unexpectedly and one wants to continuously monitor BP while arterial access is gained.”

-- Joseph Tobias, M.D., Chief of Anesthesiology, Nationwide Children’s Hospital, Columbus, Ohio, USA

“For anesthesia in elderly patients stable cardiovascular conditions during the entire surgical procedure are essential for a good outcome. For this purpose, close meshed blood pressure monitoring and also enhanced hemodynamic monitoring are very important and increase patient safety. This could just as well apply for extended high risk surgery but also for shorter procedures. Invasive arterial cannulation in elderly patients with systemic arteriosclerosis cannot be applied without certain concerns and could be technically difficult to carry out. Especially in this patient group CNAP^® HD is an easy-to- apply, risk-free and reliable method for continuous non-invasive hemodynamic monitoring.”

-- OA Dr. Günther Sumann, Department of Anaesthesia and Intensive Care, Hospital Bregenz, Austria

“I clearly see the clinical application areas of the CNAP^® HD Monitor in all patients at high cardiovascular risk where invasive blood pressure measurement with an arterial line is not necessarily justified due to the length and the severity of the procedure. It also seems useful for the hemodynamic monitoring already before anesthetic induction to avoid unnecessary stress for the patient by placing an arterial catheter.”

-- Prim. Dr. Alexander Kulier, Head of Dpt. of Anesthesiology, Krankenhaus der Elisabethinen, Linz, Austria

INTENSIVE CARE

“In conclusion, in ICU patients, the CNAP^® system shows reasonable accuracy and precision for the determination of mean and diastolic AP compared with the criterion standard (invasive arterial catheter.)”

-- Dr. Julia Nicklas, Center of Anesthesiology and ICU, University Medical Center, Hamburg-Eppendorf, Germany

EMERGENCY

“The first hours in the emergency department may be crucial for the patient in terms of physical long-term damage or survival. A continuous noninvasive arterial pressure monitoring technology like the CNAP^® system might help to increase patient safety.”

-- Dr. Julia Nicklas, Center of Anesthesiology and ICU, University Medical Center, Hamburg-Eppendorf, Germany

References:

[1] Ilies C, Kiskalt H, Siedenhans D, Meybohm P, Steinfath M, Bein B, Hanss R. Detection of hypotension during Caesarean section with continuous non-invasive arterial pressure device or intermittent oscillometric arterial pressure measurement. Br J Anaesth. 2012 Sep;109(3):413-9. doi: 10.1093/bja/aes224. Epub 2012 Jul 12. PMID: 22798273.

MORE THAN 1,000 PEER-REVIEWED PUBLICATIONS WORLDWIDE

More than 1,000 peer-reviewed publications show the utility of the CNAP^® technology in a wide range of clinical & research contexts.